• Back Issues >
  • BioOptics World >
  • Volume 6, Issue 5
  • Volume 6, Issue 5

    Prof. Yoon-Kyoung Cho and student Tae-Hyeong Kim (top), and the Caffeine Orange microfluidics device (bottom), which uses lab-on-a-disc technology developed at UNIST to extract and measure caffeine.
    Fluorescence

    Fluorescent lab-on-a-chip device detects caffeine

    Sept. 26, 2013
    For most people, it would be crazy to imagine going one day without consuming a caffeinated drink such as coffee, tea, cola, or an energy drink to stay alert.
    1309end Fig1
    Spectroscopy

    'Smart sock' could monitor baby's vital signs at home

    Sept. 26, 2013
    All parents want the peace of mind that their children are safe and breathing well.
    1309croghan
    Biophotonics Tools

    FIBER OPTICS/BIOMEDICAL DEVICE ENGINEERING: Sterilization for success: Applying optical fiber in biomedicine

    Sept. 26, 2013
    Sterilization of components is a critical step in the manufacture of biomedical devices. As demonstrated by a new study of sterilization techniques on various types of optical...
    FIGURE 1. Three-millimeter OD raster scanning endoscope components and setup. (a) Mechanical assembly of the endoscope components; (b) photograph of the prototype; (c) optical path of the internal components of the distal end; and (d) unaveraged, unstained multiphoton endoscope image of in vivo rat liver located approximately 20 μm below organ surface. The pseudo-color image shows grey SHG signal (less than 405 nm) and green intrinsic fluorescent emission (420 to 690 nm). Visible are 20- to 30-μm-diameter hepatocytes with a dark, 5- to 10-μm-diameter nucleus (N) and bright surrounding cytoplasm (C), hepatic chords (HC) composed of chains of hepatocytes, and a hepatic sinusoid (HS)—the blood-filled space between hepatic chords, bile ductile (BD), bile salts (BS), septa (S)—a fine fibrillar connective tissue that covers the surface of the hepatocytes, and a hepatic venule (HV).
    Fluorescence

    CLINICAL ENDOSCOPY/MULTIPHOTON IMAGING/FIBER OPTICS: Multiphoton endoscopy for clinical applications

    Sept. 26, 2013
    Multiphoton microscopy is a label-free technique valuable for its ability to image unprocessed biological tissues at high resolution and in real time. Multiphoton endoscopy (MPE...

    More content from Volume 6, Issue 5

    (All images courtesy of Elizabeth Hillman)
    In vivo, 3D two-photon microscopy of mouse somatosensory cortex showing astrocyte (star-shaped glial cells) locations and interactions with vessels in a selected plane. Field of view: 250 × 250 × 500 μm volume.
    Neuroscience

    NEUROSCIENCE/BIOPHOTONICS: The BRAIN Initiative: Opportunities for optics and photonics

    Sept. 26, 2013
    The Brain Research through Advancing Innovative Neurotechnologies (BRAIN) initiative is destined to survive in some form, even if the U.S. Congress does not pass the president...
    (Image courtesy of Olympus America)
    FIGURE 1. An Olympus multiphoton microscope and a 4 mm SCALEVIEW-matched 25x objective created this image of 4 mm of depth through a SCALEVIEW-cleared mouse brain. The image was isosurface-rendered and blended in Imaris from Bitplane Scientific Software. The side panels show z-panels at 1 mm intervals.
    Fluorescence

    MICROSCOPY/DEEP TISSUE IMAGING: Deeper focus in microscopic bioimaging

    Sept. 26, 2013
    Advanced clearing agents, optimized objectives, and innovative light sources allow deeper imaging inside specimens -- including living organisms.
    1309bowrademaker Frontis
    Spectroscopy

    ENVIRONMENTAL MONITORING/SPECTROSCOPY: Crowd-sourced measurements offer a unique view of pollution's effects

    Sept. 25, 2013
    Equipping thousands of citizen scientists with inexpensive, spectroscopic smartphone add-ons, a group of Dutch researchers recently facilitated a country-wide project to measure...
    Theradome's LH80 laser helmet is the first and only over-the-counter wearable laser treatment for use in the home that is FDA-approved.
    Biomedicine

    LASER LIGHT THERAPY/HAIR RESTORATION: Crowdfunding succeeds for at-home laser hair-growth device

    Sept. 25, 2013
    In early August, medical device company Theradome (Pleasanton, CA) announced the market release of its FDA-approved LH80 laser helmet, which offers clinical- strength hair growth...
    German researchers at the University of Würzburg consider this sCMOS camera critical to their investigations of African sleeping sickness.
    Fluorescence

    MICROSCOPY/LIVE CELL IMAGING: sCMOS cameras enable understanding of sleeping sickness infection

    Sept. 25, 2013
    African sleeping sickness, or trypanosomiasis, kills 30,000 people every year, in addition to entire herds of buffalo and cattle.
    1309bownews Fig1
    Microscopy

    MOBILE HEALTH/BIOPHOTONICS: Biophotonics well represented among XPRIZE competitions

    Sept. 25, 2013
    The Nokia Sensing XCHALLENGE, a program designed to facilitate the development of sensing innovations able to promote the health of individuals, has announced 12 finalist teams...
    1309bownews Fig2
    Spectroscopy

    PULSE OXIMETRY/HEALTH MONITORING: 'Best paper' describes pulse oximetry-enhanced hard hat to warn workers of CO danger

    Sept. 25, 2013
    A pulse oximetry system, integrated into a standard "hard hat," can protect construction workers from carbon monoxide (CO) poisoning.
    (Image courtesy of Tom Grunert/University of Veterinary Medicine Vienna)
    A new FTIR spectroscopy approach distinguishes aggressive strains of Staph bacteria.
    Spectroscopy

    SPECTROSCOPY/EPIDEMIOLOGY: FTIR approach quickly, accurately IDs aggressive Staph bacteria

    Sept. 25, 2013
    A new infrared (IR) spectroscopy technique operates without the use of complex antibodies to quickly distinguish between strains of Staphylococcus aureus (S. aureus) bacteria,...
    1309bowbreak Fig4
    Fluorescence

    MICROSCOPY/CELL BIOLOGY/IMMUNOLOGY: Super-resolution microscopy settles debate over nuclear pore complex, clarifies immune cell function

    Sept. 25, 2013
    Super-resolution optical microscopy has recently enabled new views of subcellular structure and operation, and in doing so promises to advance drug development, among other endeavors...
    1309bowbreakf1
    Microscopy

    STIMULATED RAMAN SCATTERING MICROSCOPY: Vibrational microscopy method generates high-res images of nascent proteins in living cells

    Sept. 25, 2013
    Researchers at Columbia University (New York, NY) report a method that enables something never before achieved: selective, high-resolution visualization of newly synthesized proteins...
    Barbaragoode2
    Microscopy

    Strategic development of biophotonics-based tools

    Sept. 25, 2013
    Many important technologies and applications have resulted from the creative efforts of researchers and end users. Probably every day, someone working with biophotonics has an...